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KMID : 0604620060130010049
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Dongguk Journal of Medicine
2006 Volume.13 No. 1 p.49 ~ p.55
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A Case of Completely Resected Advanced Gastric Carcinoma Following Neoadjuvant Chemotherapy with TS-1
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zang Dae-Young
Park Sung-Dong
Park Keon-Uk
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Abstract
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TS-1, a novel oral anticancer drug is dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine. In some clinical studies, TS-1 has shown effective anti-tumor activity in far advanced gastric cancer patients as neoadjuvant chemotherapy. Here we report our experience with a patient of advanced gastric cancer given 4 cycles of TS-1 as neoadjuvant chemotherapy before complete gastric resection. The patient was an 85-year-old man who was diagnosed with advanced gastric carcinoma that had invaded the pancreas and the paraaortic lymph nodes, before treatment. New oral anticancer drug, TS-1 (80 mg/day) was orally administered for 4 weeks followed by drug-free 2-week period as 1 cycle. Total 4 cycles of TS-1 was administered. No serious drug adverse reaction was observed except for grade 1 diarrhea and grade 3 anemia. After 4 cycles of chemotherapy, follow-up abdominal CT scan showed partial response of primary lesion and regional lymph node metastasis. The lesions in the pancreas tissues and enlarged paraaortic lymph node were not observed. The patient underwent curative surgery, including total gastrectomy and D2 lymph node dissection and the pathologic staging was T3, N2, P0, CY0, H0, M0(Stage IIIB). The patient has been survived without recurrence for seven months after the surgery.
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KEYWORD
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stomach neoplasms, neoadjuvant therapy, TS-1
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